The most common reason depressed patients discontinue tricyclic antidepressants is

• A. Dry mouth
• B. Weight gain
• C. Dizziness when standing up
• D. Cardiac toxicity

Answer: (B)

Weight gain is the most common reason depressed patients stop taking tricyclic antidepressants. These medications often increase appetite and can alter metabolic processes, leading to noticeable and persistent weight gain. For many patients, changes in body weight affect self-image and quality of life, making adherence difficult over time. Other side effects like dry mouth, dizziness on standing (orthostatic hypotension), or sedation are uncomfortable, but they’re typically more tolerable or easier to manage in the long run. Cardiac toxicity is a serious risk, especially in overdose or with preexisting heart conditions, but it is not the everyday reason patients discontinue use.